A Study of Atezolizumab (Anti-PD-L1 Antibody) plus Bevacizumab versus Active Surveillance as Adjuvant Therapy in Patients with Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation

A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation

  • Tumori
  • Carcinoma epatocellulare (HCC)
Lo stato dell'arruolamento dello studio presso il proprio centro locale potrebbe differire da quello complessivo dello studio, in quanto alcuni centri dello studio potrebbero arruolare i pazienti prima di altri.
Stato dello studio:

Attiva, non in fase di reclutamento

Questo studio si svolge in
Città
  • Adana
  • Auckland
  • Badajoz
  • Bahia
  • Baltimore
  • bei-jing-shi
  • beng-bu-shi
  • Besançon
  • Bobigny
  • Bonheiden
  • Bonn
  • Borama
  • Brno-Bohunice
  • Bunkyo City
  • Busan
  • Chang Wat Chiang Rai
  • chang-chun-shi
  • Changhua County
  • Cheng Du Shi
  • Chiba
  • Chongqing
  • Ciudad de México
  • Daegu
  • Dalian
  • Dallas
  • Darlinghurst
  • Detroit
  • Distrito Federal
  • Francoforte sul Meno
  • fu-zhou-shi
  • Fuzhou
  • Graz
  • guang-zhou-shi
  • hang-zhou-shi
  • Harbin
  • he-fei-shi
  • Hefei Shi
  • Himeji
  • Hiroshima
  • Hlavní město Praha
  • Hong Kong Island
  • Houston
  • Jinan
  • Kanazawa
  • Kaohsiung City
  • Klagenfurt am Wörthersee
  • Krung Thep Maha Nakhon
  • Kumamoto
  • La Tronche
  • Lima
  • Los Angeles
  • Maastricht
  • Madrid
  • Majadahonda
  • Marseille
  • Matsuyama
  • Milano
  • Minato City
  • Monterrey
  • Montréal
  • Mosca
  • Moskva
  • Musashino
  • nan-jing-shi
  • nan-ning-shi
  • Nanchino
  • New Territories
  • New York
  • Nishinomiya
  • Nižnij Novgorod
  • oaxaca-de-juarez
  • Osaka
  • Osakasayama
  • Paraná
  • Parma
  • Pessac
  • Philadelphia
  • Porto Alegre
  • Regensburg
  • Reims
  • Rennes
  • Roeselare
  • Sagamihara
  • San Pietroburgo
  • San Rafael
  • Sapporo
  • Seattle
  • Seongnam-si
  • Seoul
  • shang-hai-shi
  • Shanghai
  • shen-yang-shi
  • Singapore
  • Surquillo
  • Suwon
  • São Paulo
  • Taipei City
  • tian-jin-shi
  • Tokushima
  • Tolosa
  • Toscana
  • Ulm
  • Ulsan
  • Vancouver
  • Vandœuvre-lès-Nancy
  • Wagga Wagga
  • Warszawa
  • Wien
  • wu-han-shi
  • Wuhan
  • Yangzhou
  • Yokohama
  • Ürümqi
Codice identificativo dello studio:

NCT04102098 2019-002491-14 2023-504303-86-00 WO41535

  • Ospedale Regionale Di Parma; Divisione Di Oncologia Medica

    ParmaItalia
  • Ospedale Maggiore Policlinico; U.O.C. di Oncologia Medica

    20122MilanoItalia
  • Asst Santi Paolo E Carlo

    20142MilanoItalia
  • Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2

    56100ToscanaItalia
  • Kaiser Permanente Los Angeles

    90027Los AngelesStati Uniti
  • Mercy Medical Center

    21202BaltimoreStati Uniti
  • Henry Ford Health System

    48202DetroitStati Uniti
  • Columbia University Medical Center

    10019New YorkStati Uniti
  • Thomas Jefferson University

    19107PhiladelphiaStati Uniti
  • The University of Texas Southwestern Medical Center at Dallas

    75390DallasStati Uniti
  • MD Anderson Cancer Center

    77030HoustonStati Uniti
  • Swedish Cancer Inst.

    98104SeattleStati Uniti
  • St Vincent's Hospital Sydney

    2010DarlinghurstAustralia
  • Riverina Cancer Care Centre

    2650Wagga WaggaAustralia
  • Lkh-Univ. Klinikum Graz

    8036GrazAustria
  • Klinikum Klagenfurt am Wörtersee; Abt.Gastroenterologie&Hepatologie,Endokrinologie

    9020Klagenfurt am WörtherseeAustria
  • Medizinische Universität Wien; Univ.Klinik für Innere Medizin III - Gastroenterologie & Hepatologie

    1090WienAustria
  • Imeldaziekenhuis

    2820BonheidenBelgio
  • AZ Delta (Campus Rumbeke)

    8800RoeselareBelgio
  • Hospital Sao Rafael - HSR

    41253-190BahiaBrasile
  • Sociedade beneficente de senhoras Hospital Sirio Libanes

    70200-730Distrito FederalBrasile
  • Hospital do Cancer UOPECCAN; Pesquisa Clínica

    85806-300ParanáBrasile
  • Hospital das Clinicas - UFRGS

    Porto AlegreBrasile
  • Hospital Alemao Oswaldo Cruz; Oncologia

    01323-020São PauloBrasile
  • Gordon & Leslie Diamond Health Care Centre

    V5Z 1M9VancouverCanada
  • McGill University Health Centre - Glen Site

    H4A 3J1MontréalCanada
  • Peking Union Medical College Hospital

    100032bei-jing-shiCina
  • Beijing Cancer Hospital

    100142bei-jing-shiCina
  • Affiliated Hospital of Bengbu Medical College

    233030beng-bu-shiCina
  • The First Hospital of Jilin University

    130021chang-chun-shiCina
  • West China Hospital, Sichuan University

    610041Cheng Du ShiCina
  • Daping Hospital of Third Military Medical University

    400042ChongqingCina
  • The Second Affiliated Hospital of Dalian Medical University

    DalianCina
  • Mengchao Hepatobiliary Hospital Of Fujian Medical University

    350025fu-zhou-shiCina
  • Fujian Cancer Hospital

    350014FuzhouCina
  • Sun Yet-sen University Cancer Center

    510060guang-zhou-shiCina
  • Cancer Center of Guangzhou Medical University

    510180guang-zhou-shiCina
  • Zhujiang Hospital, Southern Medical University

    510280guang-zhou-shiCina
  • Nanfang Hospital, Southern Medical University

    510515guang-zhou-shiCina
  • Zhejiang Cancer Hospital; Zhejiang Cancer Hospital cancer department

    310022hang-zhou-shiCina
  • Harbin Medical University Cancer Hospital

    HarbinCina
  • Anhui Province Cancer Hospital

    230031Hefei ShiCina
  • Anhui Provincial Hospital

    230061he-fei-shiCina
  • The Second Affiliated Hospital of Anhui Medical University

    230022he-fei-shiCina
  • Shandong Cancer Hospital

    250117JinanCina
  • The 81st Hospital of P.L.A.

    210002NanchinoCina
  • Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

    210008nan-jing-shiCina
  • Zhongda Hospital Affiliated to Southeast University

    210018nan-jing-shiCina
  • Guangxi Cancer Hospital of Guangxi Medical University

    530021nan-ning-shiCina
  • The First Affiliate Hospital of Guangxi Medical University

    530021nan-ning-shiCina
  • Zhongshan Hospital Fudan Unvierstiy

    200031shang-hai-shiCina
  • Huashan Hospital Affiliated to Fudan University

    200031shang-hai-shiCina
  • Fudan University Shanghai Cancer Center

    ShanghaiCina
  • Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

    200127shang-hai-shiCina
  • The First Affiliated Hospital of China Medical University

    110001shen-yang-shiCina
  • Shengjing Hospital of China Medical University

    110055shen-yang-shiCina
  • Tianjin Cancer Hospital

    300060tian-jin-shiCina
  • The Tumor Hospital of Xinjiang Medical University

    830091ÜrümqiCina
  • Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology

    430014wu-han-shiCina
  • Renmin Hospital of Wuhan University

    430064WuhanCina
  • Zhongnan Hospital of Wuhan University

    430071wu-han-shiCina
  • Hubei Cancer Hospital

    430079wu-han-shiCina
  • Northern Jangsu People's Hospital

    225001YangzhouCina
  • Clinica CIMCA

    San RafaelCosta Rica
  • Fakultni nemocnice Brno; Interni hematologicka a onkologicka klinika

    625 00Brno-BohuniceCzechia
  • Fakultni Thomayerova Nemocnice; Onkologicke Oddeleni

    Hlavní město PrahaCzechia
  • Hopital Jean Minoz; Oncologie

    25000BesançonFrancia
  • Hôpital Avicenne - Groupement Hospitalier Universitaire Paris Seine St Denis; Service d'Hépatologie

    93000BobignyFrancia
  • Hôpital Albert Michallon

    38700La TroncheFrancia
  • Fondation Hopital Saint Joseph; Gastro-Enterologie

    MarseilleFrancia
  • CHU Bordeaux - Hôpital Haut-Lévêque; Service d?Hépato-Gastroentérologie et d Oncologie digestive

    33600PessacFrancia
  • Hopital Robert Debre; Gastro Enterologie

    51100ReimsFrancia
  • Hopital de Pontchaillou; Service Hepato Gastro Enterologie

    35000RennesFrancia
  • CHU de Toulouse - Hôpital Rangueil

    31400TolosaFrancia
  • Hopitaux de Brabois - Gastro-Entereologie

    54500Vandœuvre-lès-NancyFrancia
  • Universitätsklinikum Bonn, Medizinische Klinik und Poliklinik I.; Onkologische Gastroenterologie

    53127BonnGermania
  • Klinik Johann Wolfgang von Goethe Uni; Zentrum der Inneren Medizin; Medizinische Klinik I

    Francoforte sul MenoGermania
  • Klinikum der Uni Regensburg; Klinik f.Innere Medizin I Abt. Hämatologie und Internistische Onkologie

    93053RegensburgGermania
  • Universitätsklinikum Ulm; Zentrum für Innere Medizin Klinik für Innere Medizin I

    89081UlmGermania
  • Chiba University Hospital

    260-8677ChibaGiappone
  • Ehime Prefectural Central Hospital

    790-0024MatsuyamaGiappone
  • Hiroshima University Hospital

    734-0037HiroshimaGiappone
  • Sapporo Kosei Genaral Hospital

    060-0033SapporoGiappone
  • Hyogo Medical University Hospital

    663-8501NishinomiyaGiappone
  • Japanese Red Cross Society Himeji Hospital

    670-8540HimejiGiappone
  • Kanazawa University Hospital

    920-8641KanazawaGiappone
  • Yokohama City University Medical Center

    232-0024YokohamaGiappone
  • Kanagawa Cancer Center

    241-8515YokohamaGiappone
  • Kitasato University Hospital

    252-0375SagamiharaGiappone
  • Kumamoto University Hospital

    860-8556KumamotoGiappone
  • Osaka Red Cross Hospital

    543-8555OsakaGiappone
  • Kindai University Hospital

    589-8511OsakasayamaGiappone
  • Tokushima University Hospital

    770-0042TokushimaGiappone
  • Toranomon Hospital

    105-8470Minato CityGiappone
  • The University of Tokyo Hospital

    113-8655Bunkyo CityGiappone
  • Japanese Red Cross Musashino Hospital

    180-0023MusashinoGiappone
  • Pusan National University Hospital

    BusanCorea del Sud
  • Kyungpook National University Hospital

    41944DaeguCorea del Sud
  • CHA Bundang Medical Center

    13504Seongnam-siCorea del Sud
  • Ajou University Medical Center

    16500SuwonCorea del Sud
  • Seoul National University Bundang Hospital

    13620Seongnam-siCorea del Sud
  • Seoul National University Hospital

    03080SeoulCorea del Sud
  • Severance Hospital, Yonsei University Health System

    03722SeoulCorea del Sud
  • Asan Medical Center

    05505SeoulCorea del Sud
  • Gangnam Severance Hospital

    06273SeoulCorea del Sud
  • Samsung Medical Center

    06351SeoulCorea del Sud
  • Seoul St Mary's Hospital

    06591SeoulCorea del Sud
  • Borame Medical Center

    Boramasomalia
  • Ulsan University Hosiptal

    44033UlsanCorea del Sud
  • Centro Medico Dalinde

    06760Ciudad de MéxicoMessico
  • Filios Alta Medicina

    64740MonterreyMessico
  • Oaxaca Site Management Organization

    68000oaxaca-de-juarezMessico
  • Maastricht University Medical Center

    6229 HXMaastrichtPaesi Bassi
  • Auckland City Hospital

    1023AucklandNuova Zelanda
  • Instituto Nacional de Enfermedades Neoplasicas

    15038SurquilloPerù
  • Clínica San Gabriel; Unidad de Investigación Oncológica de la Clínica San Gabriel

    LimaPerù
  • Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie; Klinika Onkologii i Radioterapii,

    00-001WarszawaPolonia
  • First Moscow State Medical University n.a. I.M. Sechenov

    119435MoskvaRussia
  • Group of companies "Medci"

    MoscaRussia
  • Clinical hospital #1, FBHI Volga district medical center, Federal Medical and Biological Agency

    Nižnij NovgorodRussia
  • Russian Scientific Center of Radiology and Surgical Technologies; Dept of Radiology

    San PietroburgoRussia
  • National Cancer Centre

    168583SingaporeSingapore
  • Tan Tock Seng Hospital; Oncology

    308433SingaporeSingapore
  • Hospital Universitario Puerta de Hierro

    28222MajadahondaSpagna
  • Hospital Universitario Infanta Cristina; Servicio de Oncologia

    BadajozSpagna
  • Changhua Christian Hospital

    500Changhua CountyTaiwan
  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    80756Kaohsiung CityTaiwan
  • National Taiwan Uni Hospital; Dept of Oncology

    100Taipei CityTaiwan
  • Taipei Veterans General Hospital; Gastroenterology Division

    112Taipei CityTaiwan
  • Chang Gung Medical Foundation - Linkou; Dept. of Hepato-Gastroenterology

    333Taipei CityTaiwan
  • Rajavithi Hospital; Division of Medical Oncology

    10400Krung Thep Maha NakhonThailandia
  • Siriraj Hospital; Medical Oncology Unit

    10700Krung Thep Maha NakhonThailandia
  • Chiang Rai Prachanukroh Hospital; Department Of Medicine

    57000Chang Wat Chiang RaiThailandia
  • Chulabhorn Hospital; Medical Oncology

    10210Krung Thep Maha NakhonThailandia
  • Adana Baskent University Hospital; Medical Oncology

    01240AdanaTurchia
  • Hospital General Universitario Gregorio Marañon; Servicio de Oncologia

    28007MadridSpagna
  • Queen Mary Hospital; Dept. Of Haematology & Oncology

    Hong Kong IslandHong Kong
  • Prince of Wales Hospital; Department of Clinical Onocology

    New TerritoriesHong Kong
    Trova centri di sperimentazione

    Le seguenti informazioni provengono dal sito web ClinicalTrials.gov a disposizione del pubblico ed è stato modificato per utenti non medici.

    Le informazioni di seguito sono tratte dal sito web "ClinicalTrials.gov", pubblicamente disponibile

    Results Disclaimer

    Riassunto dello studio

    Lo studio in oggetto valuterà l’efficacia e la sicurezza della terapia adiuvante con atezolizumab + bevacizumab rispetto alla sorveglianza attiva in partecipanti con carcinoma epatocellulare (HCC) sottoposto a resezione o ablazione in toto che sono ad alto rischio di recidiva della malattia.

    Hoffmann-La Roche Sponsor
    Fase III Fase
    NCT04102098, WO41535, 2019-002491-14, 2023-504303-86-00 Codice identificativo dello studio
    Atezolizumab, Bevacizumab Trattamenti
    Carcinoma epatocellulare Condizione
    Titolo ufficiale

    Studio di fase III, multicentrico, randomizzato aperto su atezolizumab (anticorpo anti-PD-L1) più bevacizumab verso sorveglianza attiva, come terapia adiuvante in pazienti con carcinoma epatocellulare ad alto rischio di recidiva dopo resezione chirurgica o ablazione

    Criteri di idoneità

    Tutti Sesso
    ≥18 Anni Età
    No Volontari sani
    Criteri di inclusione

    Per ulteriori informazioni riguardanti lo studio e i criteri di inclusione, clicca sul seguente codice: NCT04102098

    Criteri di esclusione

    Per ulteriori informazioni riguardanti lo studio e i criteri di esclusione, clicca sul seguente codice: NCT04102098

     

    A proposito di studi clinici

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